I think it depends very much on the question at hand. Generally I'd advise against it, and most questions I've seen specifically address how to be honest without being rude, or something alike. However, there are cases where lying would be convenient to the OP for a myriad of reasons, all very relative and varying with each question - and, naturally, varying in the "size" of the lie.
If OP stated they do not wish to lie, or would rather not give an answer they're not comfortable with, I think it's out of the question to suggest a lie. It would not be helpful, would likely cause OP to face issues they were trying to avoid in the first place, it's considered highly unethical for a lot of people, etc. I personally believe there is always a good honest answer to a question, even if a lie would fit just nicely.
There are the odd cases where lying is fitting, but again, depends heavily on what OP requests. For instance, if OP requested a quick way to get out of a uncomfortable situation, and they were not going to face that situation ever again or not very often, and if they were not bothered about their relationship with whom they're lying to, then a lie wouldn't be necessarily bad. It would also be fit for when OP doesn't want to disclosure personal information but finds that being closed about it is not helping, or that persisting on an honest/neutral approach is proving no results.
Allow me to give a personal example: after coming out to my mom, she didn't take it very well - didn't argue, but didn't seem accepting either, by going on and on about how I wouldn't/couldn't be sure of it, etc. After that, she'd sometimes make remarks about me "fancying" a girl friend or if any "cute girl" had hit on me in a party. I decided it's best to act upon it with a white lie to avoid going on a sexuality tangent on what would be an otherwise small talk - which wouldn't be a problem if it didn't happen so often. So it usually goes as follows:
Mom: Looking good, any girl you're seeing?
Me: Nah, just going out with friends.
Mom: Did any girl hit on you?
Me: Not really.
Of course, in these examples it's not as much lying as it is avoiding the subject. But there were cases where I did straight up lie just to get over with it:
Mom: Why don't you get a girlfriend?
Me: Meh, not thinking about it right now. Got this project/job/course in mind, [goes on about that instead].
My general rule of thumb though is to always try to be honest, and expect people to understand/respect your decision/request. If OP can't/won't be open about the subject matter, and if avoiding the subject is difficult, and if they've explicitly stated they don't mind what answers they give, then sure. After all, at the end of the day, it's OP's choice as to whether they'll lie or not. We're merely suggesting it. We also shouldn't vote based on whether the answer suggests a lie or not, but whether it addresses the question properly, gives a solid/valid solution to OP's problem, and acknowledges OP's requests as to how the answers should be managed.